Mechanisms of the Antibacterial Activity of Lactoferrin and Lactoferrin-derived Peptides
نویسندگان
چکیده
Lactoferrin (Lf), a member of the transferrin family of iron-binding proteins, is now known to have a number of properties, including antibacterial activity towards a broad spectrum of Gram-negative and Gram-positive bacteria. The mechanism of the antibacterial activity of Lf is complex and involves beside iron-chelation, direct action on bacteria and/or the activation of the immune system. Lactoferricin (Lfcin) and other peptides derived from Lf or Lfcin are more potent antibacterial agents, a property exhibited by interaction with and penetration of bacterial membrane. This article summarizes the current data on the mechanisms through which Lf and Lf-derived peptides exhibit their antibacterial activity.
منابع مشابه
The Identification of a Novel Peptide Derived from Lactoferrin Isolated from Camel Milk with Potential Antimicrobial Activity
Background and Objective: Antimicrobial peptides have attracted significant attention in recent decades because of their properties, such as rapid bactericidal effects, having a wide spectrum of activity, and a rare development of drug resistance. The purpose of this study was to examine the antibacterial activity of a peptide derived from the lactoferrin isolated from camel milk against Staphy...
متن کاملThe Antifungal Activity of Lactoferrin and Its Derived Peptides: Mechanisms of Action and Synergy with Drugs against Fungal Pathogens
Lactoferrin is a multifunctional iron-binding glycoprotein belonging to the transferrin family. It is found abundantly in milk and is present as a major protein in human exocrine secretions where it plays a role in the innate immune response. Various antifungal functions of lactoferrin have been reported including a wide spectrum of activity across yeasts and molds and synergy with other antifu...
متن کاملIn silico investigation of lactoferrin protein characterizations for the prediction of anti-microbial properties
Lactoferrin (Lf) is an iron-binding multi-functional glycoprotein which has numerous physiological functions such as iron transportation, anti-microbial activity and immune response. In this study, different in silico approaches were exploited to investigate Lf protein properties in a number of mammalian species. Results showed that the iron-binding site, DNA and RNA-binding sites, signal pepti...
متن کاملExtraction and Purification of Lactoferrin from Camel Milk and Investigation of Its Amylase Activity
Background and purpose: Lactoferrin is found in mucus, milk, and colostrum secretions and has antimicrobial activities, improves iron absorption, and enhances immune responses. Lactoferrin has the ability to degrade starch. The aim of this study was to investigate the preservation of milk lactoferrin enzymatic activity after purification by ion exchange chromatography. Materials and methods: ...
متن کاملSynergy between Dairy Peptides and Proteins
α s2-casein f(183-207) and lactoferricin [lactoferrin f(17-41)] are two potent 3 antibacterial peptides derived from bovine milk proteins. The aim of this work was to 4 evaluate if the antimicrobial activity of natural compounds employed in food 5 preservation such as nisin could be enhanced by combination with the aforementioned 6 milk peptides. Combinations with lactoferrin were also performe...
متن کامل